Association between C677T Polymorphism of Methylene Tetrahydrofolate Reductase and Congenital Heart Disease: Meta-Analysis of 7,697 Cases and 13,125 Controls Running title: Mamasoula: MTHFR C677T polymorphism and congenital heart disease
نویسندگان
چکیده
Research, Eunice Kennedy Shriver National Inst of Child Health & Human Development, National Institutes of Health, Dept of Health & Human Services, Bethesda, MD; Congenital Malformations Registry, New York State Dept of Health, Troy & Dept of Epidemiology & Biostatistics, Univ at Albany School of Public Health, Rensselaer; Wadsworth Center, New York State Dept of Health, Albany, NY; Dept of Pediatrics & Communicable Diseases, The Univ of Michigan Medical School, Ann Arbor, MI; Commisariat à l’énergie Atomique (CEA), Institut Genomique, Centre National de Genotypage, Evry; Fondation Jean Dausset, Centre d’Etude du Polymorphisme Humain, Paris, France; Dept of Cardiovascular Medicine, Oxford University, Oxford; Inst of Genetics, Nottingham University, Nottingham; East Midlands Congenital Heart Centre, University Hospitals of Leicester NHS Trust, Leicester; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne; Bristol Royal Hospital for Children, Bristol, United Kingdom; The Children’s Hospital at Westmead, Westmead, Australia; Academic Medical Center, Amsterdam, The Netherlands; Inst of Medical Genetics, University of Zurich, Switzerland; Pediatric Cardiology, Center for Human Genetics, Univ of Leuven, Leuven, Belgium; Institute of Cardiovascular Sciences, The Univ of Manchester, Manchester, UK † Present address: Illumina Inc. San Diego, CA
منابع مشابه
Association between C677T polymorphism of methylene tetrahydrofolate reductase and congenital heart disease: meta-analysis of 7697 cases and 13,125 controls.
BACKGROUND Association between the C677T polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene and congenital heart disease (CHD) is contentious. METHODS AND RESULTS We compared genotypes between CHD cases and controls and between mothers of CHD cases and controls. We placed our results in context by conducting meta-analyses of previously published studies. Among 5814 cases wi...
متن کاملAre polymorphisms in MTRR A66G and MTHFR C677T genes associated with congenital heart diseases in Iranian population?
Background: The 5, 10-methyleneterahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are two essential enzymes involved in folate metabolism. The relationship between genetic polymorphisms and congenital heart defects (CHDs) is inconsistent. Our aim was to investigate the association between two well-known polymorphisms of MTHFR and MTRR genes, C677T and A66G, respectively,...
متن کاملAssociation of Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T and A1298C Polymorphisms with Myocardial Infarction From North of Fars Province
Background: The association between Methylene tetrahydrofolate reductase polymorphism and Coronary Artery diseases risk has been both confirmed and refuted in a number of published studies. The aim of this study was to investigate whether genetic polymorphisms of MTHFR (C677T, A1298C) contributed to the development of myocardial infarction (MI). Materials and Methods: The present case-contro...
متن کاملAssociation between 5, 10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and congenital heart disease: A meta-analysis☆
BACKGROUND Inconsistent results were reported in recent literature regarding the association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and the susceptibility of congenital heart disease (CHD). In this study, we performed a meta-analysis to investigate the associations by employing multiple analytical methods. METHODS Literature search was performed and pub...
متن کاملGenetic polymorphism of methylenetetrahydrofolate reductase as a potential risk factor for congenital heart disease
BACKGROUND A meta-analysis of polymorphism C677T (rs1801133) of the methylene tetrahydrofolate reductase (MTHFR) gene as a potential risk factor for congenital heart disease (CHD) in Chinese paediatric population was studied in view of the previously reported controversial results. METHODS We searched literature including PubMed, Embase, Cochrane Library, CNKI, Wanfang, and VIP databases that...
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